HAROLD J. WANEBO, M.D.; BAYARD D. CLARKSON, M.D.
Essential or "Waldenström's" macroglobulinemia was first described by Waldenström (1) in 1944, and since then it has been reported with increasing frequency (2-6). It is a disease characterized by abnormal proliferation of cells that are generally described as atypical lymphoid cells and the presence in the serum of a high molecular weight globulin
that is quite homogeneous on electrophoresis. This paper describes a patient with the characteristic findings of Waldenström's macroglobulinemia in whom macroglobulin was demonstrated in the cytoplasm of certain cells in the spleen by immunofluorescent techniques; these studies were correlated with the morphologic appearance of the cells when
WANEBO HJ, CLARKSON BD. Essential Macroglobulinemia: Report of a Case Including Immunofluorescent and Electron Microscopic Studies. Ann Intern Med. 1965;62:1025–1045. doi: 10.7326/0003-4819-62-5-1025
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Published: Ann Intern Med. 1965;62(5):1025-1045.
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