Paul A. Owren, F.A.C.P.
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Secondary thrombosis has an important role in the clinical course of coronary atherosclerotic disease. The initial reactions in thrombus formation include: (1) Adhesion of blood platelets to damaged endothelium and to collagen fibres, (2) release of adenosine diphosphate (ADP) by contact of platelets with collagen, and (3) reversible platelet aggregation in the presence of ADP, calcium, and the anti-Willebrand factor (the bleeding factor lacking in von Willebrand's disease). All these reactions are independent on the blood coagulation systems.
No general factors are known that influence the two first reactions. The third reaction, which produces loose platelet thrombi, is largely determined
Owren PA. The American College of Physicians Honorary Fellowship Lecture: Coronary Thrombosis: Its Mechanism and Possible Prevention by Linolenic Acid.. Ann Intern Med. ;62:1068–1069. doi: 10.7326/0003-4819-62-5-1068_2
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Published: Ann Intern Med. 1965;62(5):1068-1069.
Cardiology, Coronary Heart Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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