Jerome W. Conn, M.D., F.A.C.P.
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Improved methods now make it possible to assess the activity of the renin-angiotensin system in man by measuring renin activity in peripheral plasma. Angiotensin II, the active octapeptide produced by this system, besides having pressor activity, stimulates adrenal secretion of aldosterone but not of cortisol. Increased release of renal renin generates more angiotensin which, in turn, increases secretion of aldosterone. This is the mechanism by which essentially all currently known states of secondary hyperaldosteronuria are produced.
Good evidence exists that release of renin is controlled by "stretch sensors" in the afferent glomerular arterioles (AGA), decreased "stretch" releasing more renin and
Jerome W. Conn. The John Phillips Memorial Award Lecture: Normal and Altered Function of the Renin-Angiotensin-Aldosterone System in Man. Application in Clinical and Research Medicine.. Ann Intern Med. 1965;62:1071. doi: 10.7326/0003-4819-62-5-1071_1
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Published: Ann Intern Med. 1965;62(5):1071.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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