Ira G. Wool, M.D.
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Development of a cell-free ribosomal system, prepared from heart muscle of rats, has afforded the means for an analysis of the mechanism whereby insulin stimulates protein synthesis. The assay was carried out in circumstances where protein synthesis was proportional to the concentration of ribosomes. Insulin added in vitro was without effect on the ability of ribosomes to catalyze transfer of radioactivity from s ribonucleic acid (RNA)-phenylalanine-C14 to protein in the presence or absence of poly U. Ribosomes from alloxan diabetic animals were less effective in the synthesis of protein than were ribosomes from normal rats. The difference was generally small
Ira G. Wool. Concerning the Mechanism of Insulin Action.. Ann Intern Med. 1965;62:1075. doi: 10.7326/0003-4819-62-5-1075_3
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Published: Ann Intern Med. 1965;62(5):1075.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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