Karl M. Knigge, Ph.D.
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The homeostatic mechanisms involved in control of the several classical pituitary-target organ systems are now know to involve neural pathways operating through the central nervous system. Major areas of neuroendocrine interest are centered about (1) biochemical nature of neural transmitter substances, (2) elucidation of excitatory and inhibitory pathways affecting release of these hypophysiotrophic substances, and (3) analysis of the role of hormone feedback in integrating these neural components.
The present report describes methods used and some results obtained when the intracerebral thyroxin titer at specific loci in the brain is artificially increased. The rationale of such experiments lies in the
Knigge KM. Feedback Control of Hormones: Action at the CNS Level.. Ann Intern Med. 1965;62:1076. doi: 10.7326/0003-4819-62-5-1076_2
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Published: Ann Intern Med. 1965;62(5):1076.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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