Albert E. Renold
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It is becoming increasingly apparent that simple, primary, absolute insulin deficiency is not likely to be the only, perhaps not even the main pathogenetic mechanism of diabetes mellitus in man. Questions are being raised as to the prevalent type of hereditary transmission of diabetes, as to the possible occurrence of a prolonged period characterized by insulin resistance rather than by insulin deficiency, and as to the deeper meaning of the frequent coexistence of diabetes mellitus with obesity. Similar questions are raised by the observations of several spontaneous and genetically transmitted syndromes in animals that are characterized by the coincidence of
Renold AE. The Lilly Lecture: Changing Concepts of the Pathogenetic Mechanisms in Diabetes Mellitus.. Ann Intern Med. ;62:1077. doi: 10.7326/0003-4819-62-5-1077_1
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Published: Ann Intern Med. 1965;62(5):1077.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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