William R. Wilson, M.D., F.A.C.P.; Ernest O. Theilen, M.D., F.A.C.P.; William E. Connor, M.D., F.A.C.P.
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The effects of stimulation and blockade of beta-adrenergic receptors on plasma free fatty acids (FFA) and blood glucose (G) were observed in eight normal subjects during a control period (A) and after hypermetabolism (B) was induced with graded doses of triiodothyronine (150-500 μg/day for 14 days). Non-heparinized venous blood was obtained before and during the fourth minute of beta-receptor stimulation (isoproterenol, 0.025, 0.05, and 0.1 μg/kg/min intravenously) before and after a beta-receptor blocker (propranolol, 0.15 mg/kg intravenously). Significant attenuation of the normal chronotropic and inotropic effects of isoproterenol in both periods by propranolol was used as an index of beta-adrenergic
Wilson WR, Theilen EO, Connor WE. Metabolic Effects of Propranolol in Normal Subjects Before and After Triiodothyronine-induced Hypermetabolism.. Ann Intern Med. ;62:1077. doi: 10.7326/0003-4819-62-5-1077_3
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Published: Ann Intern Med. 1965;62(5):1077.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology, Rhythm Disorders and Devices.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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