Alfred Gellhorn, M.D., F.A.C.P.; William Benjamin, M.D.
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Insulin has been demonstrated to produce many changes in metabolism in the normal and diabetic organism with such complex interrelationships that the fundamental site or sites of action of the hormone are not yet fully known. Evidence, however, from studies of isolated tissues as well as the intact animal have revealed specific stimulatory actions of insulin on glucose transport across certain cell membranes, intracellular glucose phosphorylation, glycogen synthetase, de novo synthesis of fatty acids from acetate, and mono-unsaturated fatty acid synthesis from saturated fatty acids. Since in most of these instances increased enzyme activity has followed the insulin administration, studies
Gellhorn A, Benjamin W. Studies on the Mechanism of Action of Insulin in Alloxan-diabetic Rats.. Ann Intern Med. ;62:1078–1079. doi: 10.7326/0003-4819-62-5-1078_3
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Published: Ann Intern Med. 1965;62(5):1078-1079.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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