Robert M. Greendyke, M.D.; Edwin M. Bradley, M.D.; Scott N. Swisher Jr., M.D., F.A.C.P.
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Experiments were conducted to assess the effects of adrenocorticotrophic hormone (ACTH) and certain adrenal corticosteroids on the in vitro phagocytic capability of human peripheral blood leukocytes for opsonized erythrocytes. In vitro addition of glucocorticoids required grossly unphysiological amounts of these compounds to effect inhibtion, and desoxycorticosterone acetate exerted no effect in any concentration studied. Intravenously administered cortisol and orally administered prednisone caused significant sequential decrease in erythrophagocytic capacity of leukocytes from normal subjects and patients with chronic adrenal cortical insufficiency. Intravenously administered ACTH showed a similar effect in normal patients but gave no effect in patients with chronic adrenal cortical
Greendyke RM, Bradley EM, Swisher SN. The Effects of Administration of ACTH and Adrenal Corticosteroids on Erythrophagocytosis (EP).. Ann Intern Med. ;62:1083–1084. doi: 10.7326/0003-4819-62-5-1083_4
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Published: Ann Intern Med. 1965;62(5):1083-1084.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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