John C. Nixon, M.D.; Donald R. Korst, M.D., F.A.C.P.; John Whalen, B.S.; Ralph L. Brandt, M.D., F.A.C.P.
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Previous attempts to measure erythropoietin levels in serum of polycythemic patients have been inconclusive. Improved bio-assay methods and response to phlebotomy are the subject of this study. Mice were made polycythemic by intermittant exposure to low oxygen tension in a hypobaric chamber. Erythropoietin activity of sera was measured in each mouse by Fe59 and reticulocytosis.
Patients (12) selected for study were clinical problems in diagnosis of either I° or II° polycythemia. Most had prior multiple phlebotomies and treatment with P32. Studies included hematology, pulmonary function, arterial oxygen saturation, uric acid, and erythropoietin levels on each of three consecutive phlebotomies in
Nixon JC, Korst DR, Whalen J, Brandt RL. Erythropoietin Response to Multiple Phlebotomy in Human Polycythemia.. Ann Intern Med. ;62:1084. doi: 10.7326/0003-4819-62-5-1084_2
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Published: Ann Intern Med. 1965;62(5):1084.
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