Heihachiro Kashiwagi, M.D.; Jeanne M. Riddle, Ph.D.; J. P. Abraham, M.D. (Associate); Boy Frame, M.D., F.A.C.P.
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A bleeding tendency is one of the salient features of Ehlers-Danlos syndrome. An altered vascular and supportive tissue structure has previously been considered to be the cause. Observations by others have demonstrated variable coagulation abnormalities on isolated cases, but a consistent defective pattern has not been recognized.
The present study is based on a hemostatic survey with ultrastructural study of platelets on four patients with classic Ehlers-Danlos syndrome. Three of the patients (all unrelated) demonstrated a normal plasma clotting time, normal partial thromboplastin test, and an abnormal prothrombin consumption time, suggestive of a functional defect of platelets. Electron microscopic study,
Kashiwagi H, Riddle JM, Abraham JP, Frame B. Functional and Ultrastructural Abnormality of Platelets in Ehlers-Danlos Syndrome.. Ann Intern Med. 1965;62:1084–1085. doi: 10.7326/0003-4819-62-5-1084_3
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Published: Ann Intern Med. 1965;62(5):1084-1085.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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