Matthew Block, M.D., Ph.D.
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Blood formation may be analyzed in terms of kinetics (the rate of production of cells) and maturation (elaboration of specific morphologic and functional features characteristic of a cell; for example, hemoglobin for transporting oxygen in a red cell).
The kinetic aspects are further analyzable in terms of (1) replication of stem cells (either fixed, stellate cells as reticular cell or free stem cells), (2) transformation of stem cell(s) into one of the cell lineages (influx, heteroplastic formation), (3) mitotic proliferation within a specific cell lineage, (4) maturation time prior to release into the circulation, and (5) wastage or ineffective hematopoiesis
Block M. General Concepts Relative to Origin, Maintenance, Proliferation, and Maturation of Hematopoietic Cells.. Ann Intern Med. ;62:1085. doi: 10.7326/0003-4819-62-5-1085_1
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Published: Ann Intern Med. 1965;62(5):1085.
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