Robert F. Schilling, M.D.; Mary Muckerheide, B.S.; Elizabeth Jacobs, M.D.; Johannes Abels, M.D.
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Sera from some patients with pernicious anemia contain globulins that will inhibit the in vivo action of intrinsic factor, or inhibit the binding of vitamin B12 by gastric juice, or change the electrophoretic mobility of gastric juice vitamin B12 complex. All sera found to inhibit vitamin B12 binding by gastric juice also inhibit intrinsic factor activity in vivo. Two thirds of the sera that block vitamin B12 binding will also change the electrophoretic mobility of the complex. One serum changes electrophoretic mobility but does not inhibit vitamin B12 binding by gastric juice or intrinsic factor activity in vivo. The exposure
Schilling RF, Muckerheide M, Jacobs E, Abels J. Multiple Auto-antibodies to Gastric Juice.. Ann Intern Med. ;62:1085. doi: 10.7326/0003-4819-62-5-1085_3
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Published: Ann Intern Med. 1965;62(5):1085.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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