James A. Reinarz; Alan K Pierce, M.D.; Jay P. Sanford, M.D.
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Gram-negative bacilli are assuming an increasing role in nosocomial infections, having surpassed staphylococci in frequency of occurrence. In addition to the well-recognized syndromes of pyelonephritis and gram-negative rod bacteremia, a characteristic necrotizing pneumonia caused by gram-negative bacilli has been identified at autopsy. Pathological characteristics include necrosis of alveolar walls and bronchioles, extensive polymorphonuclear infiltration, and large numbers of gram-negative bacilli. Its frequency in autopsies at Parkland Memorial Hospital increased from 3% in 1935 to 10% in 1963 (P < 0.01). This report describes a group of patients with fatal necrotizing pneumonia selected to illustrate potential factors in its pathogenesis.
Reinarz JA, Pierce AK, Sanford JP. Acute Gram-negative Bacillary Necrotizing Pneumonia: An Inquiry into Its Pathogenesis.. Ann Intern Med. 1965;62:1086. doi: 10.7326/0003-4819-62-5-1086_2
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Published: Ann Intern Med. 1965;62(5):1086.
Infectious Disease, Pneumonia, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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