Robert L. Wall, M.D., F.A.C.P.; John McConnell, M.S.; Delma Moore, R.N., M.T.
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The Amish are a religious sect having a stable inbred population unchanged in recent years by additions to the sect by immigration and rarely by non-Amish marriage. They represent a unique group for genetic study. Christmas disease (Factor IX deficiency) has been observed in this kindred as well as deutan color blindness.
A large kindred arising from a marriage of 1875, now numbering over 600 individuals, contains the Christmas disease patients. Over 500 of this family have been bled for assay of Factor IX by a modification of Ratnoff's partial thromboplastin method, tested for color blindness, and typed for the
Wall RL, McConnell J, Moore D. Christmas Disease and Color Blindness in the Amish.. Ann Intern Med. ;62:1088. doi: 10.7326/0003-4819-62-5-1088_1
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Published: Ann Intern Med. 1965;62(5):1088.
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