Burton A. Waisbren, M.D., F.A.C.P.; James W. Hainer, B.S.; Irving Lutsky, V.M.D.; Theofilos Tsaqaris, M.D.
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This investigation was undertaken to see if the injection of living gram-negative bacilli into dogs would give a picture more similar to gram-negative shock in humans than that seen after the injection of endotoxin into dogs. The first dog injected intravenously with living Escherichia coli proved to be resistant not only to large numbers of living organisms but also to a concentration of 10 mg/kg of endotoxin (that is, five times the lethal dose). Forty-eight of the next 50 dogs injected with living E. coli died in spite of the therapy of chloramphenicol, hydrocortisone, and the combination of chloramphenicol and
Waisbren BA, Hainer JW, Lutsky I, Tsaqaris T. Gram-negative Bacteremia in Dogs.. Ann Intern Med. ;62:1089. doi: 10.7326/0003-4819-62-5-1089_2
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Published: Ann Intern Med. 1965;62(5):1089.
Infectious Disease, Multi-Organ Failure and Sepsis, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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