Nathaniel B. Kurmick, M.D., F.A.C.P.; Barbara Hicks
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Transplantation of immunity by injection of immunized spleen cells indicates that production of antibodies is a positive transferable characteristic. The demonstration of transplantability of tolerance in the same manner would suggest that this is also a positive transferable characteristic. Lethally irradiated CF No. 1 mice were injected intravenously with spleen cells from (1) donors previously immunized against rat red blood cells, (2) donors made tolerant by intracardiac injection of rat red blood cells at birth, and (3) normal donors. Mice injected with normal spleen cells did not
develop rat red blood cell agglutinins spontaneously but did develop immunity when challenged
Kurmick NB, Hicks B. Transplantation of Tolerance.. Ann Intern Med. ;62:1091. doi: 10.7326/0003-4819-62-5-1091_1
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Published: Ann Intern Med. 1965;62(5):1091.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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