RICHARD L. LANDAU, M.D.; ATTALLAH KAPPAS, M.D.
The studies reported here were prompted by efforts to ameliorate or control the metabolic abnormalities of a patient with hyperparathyroidism due to a functional disseminated parathyroid carcinoma. The impressive loss of bone substance and the concomitant soft tissue wasting in this patient suggested the possibility that treatment with anabolic hormones might ameliorate or reverse these changes. He received, therefore, two short courses of pituitary growth hormone and testosterone propionate for a month. This therapy resulted in a significant shift in the biochemical abnormalities toward normal and thus a more favorable clinical outlook. Anabolic sex hormones (testosterone and estradiol) also diminished
LANDAU RL, KAPPAS A. Anabolic Hormones in Hyperparathyroidism: With Observations on the General Catabolic Influence of Parathyroid Hormone in Man. Ann Intern Med. ;62:1223–1233. doi: 10.7326/0003-4819-62-6-1223
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Published: Ann Intern Med. 1965;62(6):1223-1233.
Endocrine and Metabolism, Parathyroid Disorders.
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