ALBERTO M. RESTREPO, M.D.; OSCAR G. LONDOÑO, M.D.
Sickle cell hemoglobin D disease, sometimes referred to as drepanocytosis hemoglobin D disease or hemoglobin S-D disease, was described initially by Itano (1) in 1951. Since that time only seven additional cases of this disease have been reported (2-8).
The present study describes the findings in an additional patient with sickle cell hemoglobin D disease.
Routine hematological studies were performed. Other methods included paper electrophoresis with veronal buffer at a pH of 8.6, electrophoresis on agar gel with citrate buffer at a pH of 6.0 (9), sickle cell preparation with 2% sodium metabisulphate (10), hemoglobin solubility in 2.8 M
RESTREPO AM, LONDOÑO OG. Sickle Cell Hemoglobin D Disease in a Negro Colombian Patient. Ann Intern Med. ;62:1301–1306. doi: 10.7326/0003-4819-62-6-1301
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Published: Ann Intern Med. 1965;62(6):1301-1306.
Hematology/Oncology, Red Cell Disorders.
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