KURT W. BRUNNER, M.D.; CHARLES W. YOUNG, M.D.
Methylhydrazine derivatives form a new class of synthetic cytotoxic compounds. They possess antineoplastic activity in animal tumor systems (1, 2) and in patients with malignant lymphoma (3, 4). The most widely studied of these derivatives is N-isopropyl-alpha-(2-methylhydrazino)-ρ-toluamide hydrochloride, (Ro 4-6467, NSC-77213) (Figure 1).1 It is reported to have teratogenic (5), immunosuppressive (6), and carcinogenic properties (7) in addition to antineoplastic activity.
The molecular mechanism by which methylhydrazine derivatives produce biological effects is unknown. Observations in noncellular systems have disclosed that methylhydrazine is autoxidized in oxygen-containing aqueous solution with formation of hydrogen peroxide and oxygen-hydrogen radicals. These, in turn, degrade deoxyribonucleic
BRUNNER KW, YOUNG CW. A Methylhydrazine Derivative in Hodgkin's Disease and Other Malignant Neoplasms: Therapeutic and Toxic Effects Studied in 51 Patients. Ann Intern Med. ;63:69–86. doi: 10.7326/0003-4819-63-1-69
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Published: Ann Intern Med. 1965;63(1):69-86.
Emergency Medicine, Hematology/Oncology, Leukemia/Lymphoma.
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