STANLEY ROSEWATER, B.A.; GRANT GWINUP, M.D.; GEORGE J. HAMWI, M.D., F.A.C.P.
Gynecomastia has been reported in association with many systemic diseases (1-8), with pituitary, gonadal, and adrenal tumors (9-11), and secondary to drug administration and starvation (12-16). Gynecomastia has also been described in various hypergonadotrophic hypogonadal states (17, 18). Several families have been reported with gynecomastia associated with hypospadias (19-21). We have studied a family in which four males have presented with gynecomastia as a part of a syndrome not previously reported. An attempt has been made to elucidate the endocrine interrelationships leading to breast development in these males and to speculate about the causative mechanism.
The protein-bound iodine (PBI)
ROSEWATER S, GWINUP G, HAMWI GJ. Familial Gynecomastia. Ann Intern Med. ;63:377–385. doi: 10.7326/0003-4819-63-3-377
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Published: Ann Intern Med. 1965;63(3):377-385.
Hospital Medicine, Lupus Erythematosus, Rheumatology.
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