JOSE RAMIREZ-R., M.D.; GUY D. CAMPBELL, M.D., F.A.C.P.
Pulmonary alveolar proteinosis is characterized pathologically by the accumulation of a lipid-rich proteinaceous material within the alveolar spaces in the absence of an inflammatory response (1). The striking roentgenographic feature is a changing pattern of acinar infiltrates that may involve any lobe but that is frequently more apparent in the central areas of the lung (2). There is no characteristic clinical pattern to the disorder. Symptoms and findings result from a progressive impairment of gas exchange or are a sequel to complicating bacterial or fungal infections. In some cases, an active pulmonary injury is suggested by persistently elevated serum levels
RAMIREZ-R. J, CAMPBELL GD. Pulmonary Alveolar Proteinosis: Endobronchial Treatment. Ann Intern Med. ;63:429–441. doi: 10.7326/0003-4819-63-3-429
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Published: Ann Intern Med. 1965;63(3):429-441.
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