LEWIS E. BRAVERMAN, M.D.; JOSEPH P. MANCINI, M.D.; DAVID M. MCGOLDRICK, M.D.
Idiopathic or primary diabetes insipidus may be a familial disease, and many families with this disorder have been reported (1-12). The hereditary form has been described as being autosomal dominant (4-6, 8, 10, 12), autosomal dominant with incomplete female penetrance (7, 11), or sex-linked recessive (4, 9). However, postmortem studies have been reported only rarely. Blotner (13) described the autopsy findings of three cases, one of which was familial. In two of these cases there was a marked loss of nerve cells in the supra-optic nuclei of the hypothalamus. The paraventricular nuclei likewise showed some cell loss but to a
BRAVERMAN LE, MANCINI JP, MCGOLDRICK DM. Hereditary Idiopathic Diabetes Insipidus: A Case Report with Autopsy Findings. Ann Intern Med. ;63:503–508. doi: 10.7326/0003-4819-63-3-503
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Published: Ann Intern Med. 1965;63(3):503-508.
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