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Tissue regeneration (as opposed to regeneration of limbs or whole organisms in lower organisms) is discussed in separate chapters on bone, striated muscle, endometrium, gastric mucosa, and skin epithelium. The basic model is the histologic examination of grafted tissues. Largely the author's own experiments and conclusions are discussed. The main thesis is that cells of the graft die and that regeneration (and differentiation) commence in a host mesenchymal blastema surrounding the dying graft. The dying graft releases inductors that diffuse out and cause the blastemal cells to differentiate. Attractive as this may appear from the histologic sections no experimental proof
Induction Phenomena in Tissue Regeneration.. Ann Intern Med. ;63:549. doi: 10.7326/0003-4819-63-3-549_1
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Published: Ann Intern Med. 1965;63(3):549.
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