N. BLAIR LEROY, M.D.; JOHN L. GUERRANT, M.D., F.A.C.P.
Asthma is a generalized obstructive pulmonary disease. Its manifestations are protean, and as a result physicians have found it difficult to agree on a definition. In recent years the CIBA Guest Symposium (1) and the American Thoracic Society (2) have suggested definitions that agree in essential points. We have followed the definition of the American Thoracic Society, which is: "Asthma is a disease characterized by an increased responsiveness of the trachea and bronchi to various stimuli and manifested by a widespread narrowing of the airways that changes in severity either spontaneously or as a result of therapy."
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LEROY NB, GUERRANT JL. Breathing Mechanics in Asthma. Ann Intern Med. 1965;63:572–582. doi: 10.7326/0003-4819-63-4-572
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Published: Ann Intern Med. 1965;63(4):572-582.
Asthma, Pulmonary/Critical Care.
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