VERNON N. HOUK; KENNETH M. MOSER, M.D., F.A.C.P.
In the past cryptococcosis has been considered a rare disease usually terminating in highly fatal meningitis. Prior to 1955 about 300 cases had been reported (1). In recent years, localized pulmonary lesions attributable to Cryptococcus neoformans occurring in the absence of extrapulmonary infection have been diagnosed by microscopic and cultural examination of resected tissue obtained at the time of diagnostic thoractomy and have seldom been diagnosed clinically (2). This has been due to the lack of an available reliable skin test antigen and relatively meager experience with serologic studies (3). It also reflects failure to consider the disease in the
HOUK VN, MOSER KM. Pulmonary Cryptococcosis: Must All Receive Amphotericin B?. Ann Intern Med. ;63:583–596. doi: 10.7326/0003-4819-63-4-583
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Published: Ann Intern Med. 1965;63(4):583-596.
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