HOWARD N. WARD, M.D.; NADYA KONIKOV, M.D.; EDWARD H. REINHARD, M.D., F.A.C.P.
In 1956 Marinho and Martins (1) first called attention to a syndrome resembling adrenocortical insufficiency that occurred after busulfan (Myleran⌖) therapy in two patients with chronic granulocytic leukemia. In 1961 Kyle, Schwartz, Oliner, and Dameshek (2) reported four patients with chronic granulocytic leukemia who developed a similar syndrome after long-term busulfan therapy. In all of Kyle's patients there were hyperpigmentation of the skin, excessive fatigue, weakness, weight loss, nausea, and occasional vomiting. However, no endocrine abnormality could be demonstrated by laboratory tests. Cytologic dysplasia may also occur after treatment with antileukemic agents as reported by Weston and Guin (3) in
WARD HN, KONIKOV N, REINHARD EH. Cytologic Dysplasia Occurring After Busulfan (Myleran⌖) Therapy: A Syndrome Resembling Adrenocortical Insufficiency and Atrophic Bronchitis. Ann Intern Med. ;63:654–660. doi: 10.7326/0003-4819-63-4-654
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Published: Ann Intern Med. 1965;63(4):654-660.
Adrenal Disorders, Endocrine and Metabolism, Infectious Disease, Pulmonary/Critical Care.
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