EDWARD C. LYNCH, M.D.; CLARENCE P. ALFREY JR., M.D.
Histiocytic medullary reticulosis was first described by Scott and Robb-Smith (1) in 1939 as a disorder in which there was proliferation of actively phagocytic histiocytes in the bone marrow, spleen, liver, and lymph nodes. Based on recent reviews of the medical literature, at least 48 cases have been described (2-4); however, very few cases have been reported in the American literature (2-6). Clinically the disease is characterized by fever, wasting, generalized lymphadenopathy, hepatosplenomegaly, anemia, leukopenia, and thrombocytopenia. An increase in monocytes (1, 3, 7) and the presence of histiocytes (3, 7, 8) have occasionally been noted on examination of the
LYNCH EC, ALFREY CP. Histiocytic Medullary Reticulosis: Hemolytic Anemia Due to Erythrophagocytosis by Histiocytes. Ann Intern Med. ;63:666–671. doi: 10.7326/0003-4819-63-4-666
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Published: Ann Intern Med. 1965;63(4):666-671.
Hematology/Oncology, Red Cell Disorders.
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