ELLIOTT MIDDLETON JR., M.D.
The purpose of this review is to draw together some considerations involving the anatomy and physiology of the normal lung, the pathology of bronchial obstruction in asthma, and the biochemical events leading to it. In so doing it is hoped to focus attention on a variety of facets of the lung in asthma not usually considered together.
Bronchial asthma is a chronic disease characterized by episodic bronchial obstruction and ventilatory insufficiency and is manifested clinically by wheezing respirations, dyspnea, cough, and mucoid sputum production. The essential pathological changes in the bronchi and bronchioles which cause these symptoms are mucosal edema,
ELLIOTT MIDDLETON. The Anatomical and Biochemical Basis of Bronchial Obstruction in Asthma. Ann Intern Med. 1965;63:695–714. doi: 10.7326/0003-4819-63-4-695
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Published: Ann Intern Med. 1965;63(4):695-714.
Asthma, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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