GRAHAM H. JEFFRIES, M.B., M.R.C.P.
Intrinsic factor, secreted by gastric parietal cells in man (1), is necessary for vitamin B12 absorption. This substance, a mucoprotein that has yet to be prepared in a pure state, combines with vitamin B12 from food and facilitates the transfer of the vitamin across the mucosa of the distal small intestine (2). In patients with pernicious anemia, the mucosal glands in the body and fundus of the stomach are atrophic and contain no parietal cells; neither hydrochloric acid nor intrinsic factor can be detected in stimulated gastric secretions, and vitamin B12 absorption is impaired. Hematologic or neurologic manifestations of vitamin
GRAHAM H. JEFFRIES. Parietal Cell Antibodies. Ann Intern Med. 1965;63:717–719. doi: 10.7326/0003-4819-63-4-717
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Published: Ann Intern Med. 1965;63(4):717-719.
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