WARREN E. GOORNO, M.D.; NORMAN M. KAPLAN, M.D., F.A.C.P.
The kidney may cause hypertension by the elaboration of a pressor material in the presence of renal ischemia. The prevailing theory is that a decrease in the pressure within the renal afferent arteriole (1, 2) causes the juxtaglomerular apparatus to release the enzyme renin (3), which in turn acts enzymatically upon a substrate in the circulation to produce the decapeptide angiotensin I. Angiotensin I is then acted upon by a converting enzyme to produce the potent pressor octapeptide, angiotensin II (4).
We have attempted to assess the role of the renal pressor mechanism in various hypertensive states. Two different methods
WARREN E. GOORNO, NORMAN M. KAPLAN. Renal Pressor Material in Various Hypertensive Diseases. Ann Intern Med. 1965;63:745–751. doi: 10.7326/0003-4819-63-5-745
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Published: Ann Intern Med. 1965;63(5):745-751.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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