VINCENT A. DISCALA, M.D.; WILLY MAUTNER, M.D.; JAY A. COHEN, M.D.; MARVIN F. LEVITT, M.D.; JACOB CHURG, M.D.; STUART L. YUNIS, M.D.
Mannitol, a polyhydric alcohol of the sugar mannose, is poorly metabolized by the body (1) and is poorly reabsorbed by the renal tubules (2). It was introduced to the renal physiology laboratory in 1940 as an agent for the measurement of glomerular filtration rate (GFR) (2) and was first used as an osmotic diuretic in 1948 (3). A report in 1960 that osmotic diuresis prevented acute renal failure after aortic cross-clamping popularized the use of mannitol as a therapeutic agent (4-6). Since then it has been used extensively as an osmotic diuretic in the treatment of many varied clinical states,
DISCALA VA, MAUTNER W, COHEN JA, LEVITT MF, CHURG J, YUNIS SL. Tubular Alterations Produced by Osmotic Diuresis with Mannitol. Ann Intern Med. ;63:767–775. doi: 10.7326/0003-4819-63-5-767
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Published: Ann Intern Med. 1965;63(5):767-775.
Hospital Medicine, Nephrology.
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