JOSE RAMIREZ-R., M.D.; RICHARD F. KIEFFER JR., M.D.; WILMOT C. BALL JR., M.D.
In 1963, it was postulated that some of the manifestations of pulmonary alveolar proteinosis resulted from an abnormality of the pulmonary clearing process (1, 2). Based on this concept, repeated pulmonary segmental flooding was introduced and successfully applied as a method of bronchiolo-alveolar debridement in the treatment of six cases of alveolar proteinosis (2-4). Subsequently, segmental infusion of therapeutic agents has been used in the treatment of other pulmonary diseases (5).
Experience with these cases showed that segments of human lung could be irrigated four times a day with 50 to 100 ml of saline solution containing heparin, acetylcysteine, or
RAMIREZ-R. J, KIEFFER RF, BALL WC. Bronchopulmonary Lavage in Man. Ann Intern Med. ;63:819–828. doi: 10.7326/0003-4819-63-5-819
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Published: Ann Intern Med. 1965;63(5):819-828.
Asthma, Chronic Obstructive Airway Disease, Hospital Medicine, Infectious Disease, Pulmonary/Critical Care.
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