MAURICIO J. DULFANO, M.D.; SADAMU ISHIKAWA, M.D.
A frequent consultation to the Lung Station in a general hospital relates to patients suspected of having "CO2 intoxication or narcosis." This diagnosis is commonly entertained when some mental or behavioral changes occur acutely in patients suffering from chronic obstructive pulmonary disease, especially during acute exacerbation of respiratory failure. The full blown picture of "CO2 narcosis" in these patients is well known, particularly through the work of Westlake, Simpson, and Kaye (1) and Sieker and Hickam (2). However, attempts to estimate clinically the degree of carbon dioxide retention in terms of the degree of mental disturbance in any such patient
DULFANO MJ, ISHIKAWA S. Hypercapnia: Mental Changes and Extrapulmonary Complications: An Expanded Concept of the "CO2 Intoxication" Syndrome. Ann Intern Med. ;63:829–841. doi: 10.7326/0003-4819-63-5-829
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Published: Ann Intern Med. 1965;63(5):829-841.
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