Ann M. Lawrence, M.D.
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Glucagon has provoked striking blood pressure elevations in two patients with documented pheochromocytoma (180/100 mm Hg to 260/140 mm Hg, and 140/90 mm Hg to 300/160 mm Hg) and in one suspected case (140/70 mm Hg to 300/ 180 mm Hg) under study. Peak rise occurred 30 to 60 seconds after rapid intravenous injection of 0.5 to 1 mg glucagon. When Regitine⌖ was administered there was prompt return of blood pressure to normal.
Intravenous glucagon produced no significant blood pressure rise when administered to 26 control subjects, including healthy individuals and patients with essential hypertension, thyrotoxicosis, diabetes mellitus, and acromegaly.
Lawrence AM. A New Provocative Test for Pheochromocytoma.. Ann Intern Med. ;63:905–906. doi: 10.7326/0003-4819-63-5-905_2
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Published: Ann Intern Med. 1965;63(5):905-906.
Adrenal Disorders, Endocrine and Metabolism, Endocrine Cancer, Hematology/Oncology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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