Milford Fulop, M.D.; John Sandson, M.D.; Paul Brazeau, Ph.D.
This content is PDF only. Please click on the PDF icon to access.
Plasma conjugated and unconjugated bilirubin were both believed to be completely protein-bound and hence unavailable for renal glomerular filtration. Our studies in dogs with ligated common bile ducts, however, suggested that glomerular filtration was the predominant mechanism of renal excretion of conjugated bilirubin. The binding of bilirubin to plasma proteins was therefore reexamined. Unconjugated bilirubin was not dialyzable from plasma. Dialysis of conjugated hyperbilirubinemic plasma did yield a small fraction of dialyzable bilirubin, sufficient to account for its renal excretion by glomerular filtration. This dialyzable plasma fraction increased in jaundiced patients who developed renal insufficiency. Paper electrophoresis of unconjugated hyperbilirubinemic
Milford Fulop, John Sandson, Paul Brazeau. The Renal Excretion of Bilirubin in Man.. Ann Intern Med. 1965;63:910. doi: 10.7326/0003-4819-63-5-910_3
Download citation file:
Published: Ann Intern Med. 1965;63(5):910.
Results provided by:
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use