George J. Brewer, M.D.
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Elevated erythrocyte ATP is a recently described inherited abnormality in which erythrocytes of some affected individuals contain levels of ATP (6.0 µm/g hemoglobin) twice the normal mean (3.1 µm). Genetic studies of this Negro kindred are consistent with simple autosomal inheritance. Genes for glucose-6-phosphate dehydrogenase (G-6-PD) deficiency and sickle hemoglobin also occur in the kindred but segregate independently. The propositus, whose erythrocytes have twice normal levels of ATP, is G-6-PD deficient. He is as susceptible to primaquine-induced hemolysis as other G-6-PD deficient subjects, and drug ingestion does not influence his erythrocytic ATP level; these findings argue strongly against one current
Brewer GJ. Clinical Implications of Studies of Erythrocytes with "Elevated Erythrocytic ATP.". Ann Intern Med. ;63:912. doi: 10.7326/0003-4819-63-5-912_1
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Published: Ann Intern Med. 1965;63(5):912.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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