Saul Krugman, M.D.
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The epidemic of rubella in the United States in 1964 was followed by the birth of many thousands of infants with congenital rubella syndrome. This syndrome was characterized by one or more of the following manifestations: (1) intrauterine growth retardation, (2) thrombocytopenic purpura, (3) eye lesions (cataract or glaucoma), (4) congenital heart disease (patent ductus arteriosus or septal defects or both), (5) brain lesions (microcephaly, hydrocephalus or meningo-encephalitis), (6) hepatosplenomegaly, (7) hepatitis, and (8) bone lesions.
Rubella virus isolatin studies by many investigators have revealed the following: (1) presence of virus in fetal tissues for weeks and months after maternal
Krugman S. Rubella and the Congenital Rubella Syndrome.. Ann Intern Med. ;63:914–915. doi: 10.7326/0003-4819-63-5-914_3
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Published: Ann Intern Med. 1965;63(5):914-915.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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