Marcus A. Rothschild, M.D., F.A.C.P.; Murray Oratz, Ph.D.; Sidney S. Schreiber, M.D., F.A.C.P.
This content is PDF only. Please click on the PDF icon to access.
In the presence of hypergammaglobulinemia, and after the administration of gamma globulin and dextran, albumin levels decrease due to a decrease in albumin production. The extravascular albumin pool is conserved. However, in the presence of cortisone and following the administration of thyroid, albumin synthesis increases with a decrease in the extravascular albumin pool. These observations coupled with the oft observed reciprocal changes in albumin and globulin levels in the serum suggested the presence of a colloid osmotic regulatory system affecting control of albumin production and also that such a system might be located in an extravascular site. Albumin metabolism and
Rothschild MA, Oratz M, Schreiber SS. Colloid Concentration and Albumin Synthesis.. Ann Intern Med. ;63:915. doi: 10.7326/0003-4819-63-5-915_2
Download citation file:
Published: Ann Intern Med. 1965;63(5):915.
Results provided by:
Copyright © 2018 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use