Alton I. Sutnick, M.D.; Louis A. Soloff, M.D.
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It has been implied that an intact pulmonary arterial circulation is required for the production of pulmonary surfactant by the alveolar epithelial cells. Pulmonary infarctions in dogs have been shown to demonstrate a decrease in surface activity, but similar findings in human lungs have not been described. In order to evaluate this phenomenon in human lungs, we have studied 19 pulmonary infarctions found at autopsy. Saline extracts were made of all specimens, and surface activity was measured on a modified Langmuir-Whilhelmy surface film balance. Only one (5.3%) demonstrated a minimal surface tension below 10 dynes/cm, a consistent finding in 21
Sutnick AI, Soloff LA. Human Pulmonary Infarctions and Surfactant Production.. Ann Intern Med. ;63:919. doi: 10.7326/0003-4819-63-5-919_2
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Published: Ann Intern Med. 1965;63(5):919.
Pulmonary Embolism, Pulmonary/Critical Care, Venous Thromboembolism.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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