George C. Griffith, M.D., F.A.C.P.; George Nichols Jr., M.D.; John D. Asher, M.D.
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Treatment of 117 men with up to 100 mg of heparin daily for 2 to 15 years in the prophylaxis of arteriosclerotic and thromboembolic disease was without apparent skeletal complications. When dosage was raised to 200 to 300 mg/day, six of ten men so treated developed marked osteoporosis by X ray, and multiple vertebral compression fractures within 2 years. Serum calcium, phosphorus, acid, and alkaline phosphatase were normal in all patients affected, as were rates of calcium, phosphorus, hydroxyproline excretion, and renal tubular resorption of phosphorus when tested. Parathyroid response to infusions of calcium and ethylenediamine-tetra-acetic acid was examined in
Griffith GC, Nichols G, Asher JD. Heparin Osteoporosis.. Ann Intern Med. ;63:921–922. doi: 10.7326/0003-4819-63-5-921_3
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Published: Ann Intern Med. 1965;63(5):921-922.
Endocrine and Metabolism, Metabolic Bone Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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