ROBERT L. PERKINS, M.D.; SAMUEL SASLAW, M.D., PH.D., F.A.C.P.
Cephalothin sodium is a semisynthetic derivative of cephalosporanic acid. The nucleus consists of fused beta-lactam and dihydrothiazine rings, thus resembling the penicillin nucleus (Figure 1). The wide antibacterial spectrum (1), penicillinase resistance (2), and apparent low toxicity (3, 4) of cephalothin present unusual advantages to the clinician. It is the purpose of this report to describe the response of 51 patients to treatment with cephalothin. In addition, studies are described in reference to comparative allergy testing with penicillin in 30 penicillin-allergic patients and to serial serum levels of cephalothin in normal volunteers.
Fifty of the patients were
PERKINS RL, SASLAW S. Experiences with Cephalothin. Ann Intern Med. ;64:13–24. doi: 10.7326/0003-4819-64-1-13
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Published: Ann Intern Med. 1966;64(1):13-24.
Hospital Medicine, Infectious Disease.
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