FORBES H. NORRIS JR., M.D.
The concurrence of thyrotoxicosis and myasthenia gravis is well-known; careful studies have demonstrated that hyperthyroidism worsens myasthenia, probably through an effect of thyroid hormone rather than pituitary thyrotropin (1, 2). Moreover, myasthenia in the case of Drachman (2) was also worse when the patient became hypothyroidal. From these and other clinical observations (3), altered neuromuscular function would be predicted in myxedema.
Myxedema and myasthenia, however, have rarely been associated. Two cases reported by Feinberg, Underdahl, and Eaton (4) and three by Sahay, Blendis, and Greene (5) seem to be the only documented examples although seven other cases have been cited
NORRIS FH. Neuromuscular Transmission in Thyroid Disease. Ann Intern Med. ;64:81–86. doi: 10.7326/0003-4819-64-1-81
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Published: Ann Intern Med. 1966;64(1):81-86.
Endocrine and Metabolism, Thyroid Disorders.
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