HAROLD L. ISRAEL, M.D., F.A.C.P.; MAURICE SONES, M.D., F.A.C.P.
A majority of patients with active sarcoidosis develop a granulomatous nodule within 6 weeks of the intracutaneous injection of suspensions prepared from spleens or lymph nodes involved by sarcoidosis. Clinical use of the Kveim reaction as a diagnostic test has been limited by difficulties in preparation and biologic standardization that seriously restrict the availability of test materials, by a hazard of deterioration resulting in loss of potency or of specificity, and by the fact that a significant number of patients with active sarcoidosis fail to react to suspensions of unquestioned potency. The Kveim reaction is nevertheless of basic importance, apparently
ISRAEL HL, SONES M. A Study of Bacillus Calmette-Guérin Vaccination and the Kveim Reaction. Ann Intern Med. ;64:87–91. doi: 10.7326/0003-4819-64-1-87
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Published: Ann Intern Med. 1966;64(1):87-91.
Infectious Disease, Vaccines/Immunization.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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