JOHN K. MILLER, M.D., F.A.C.P.; FREDERICK HESSER, M.D., F.A.C.P.; VICTOR N. TOMPKINS, M.D.
The development of methods for cultivation of viruses and of improved antigens makes possible improved etiologic identification in some of the encephalitides. It is increasingly recognized that most cases of herpes encephalitis present a diffuse lesion. However, the signs and symptoms, including those adduced by the angiogram and the electroencephalogram, may also simulate a brain abscess or brain tumor.
This series is comprised of 20 patients observed during a 10-year period. The first five cases were fatal. Herpes simplex virus was isolated from the brain of four patients. In the fifth case, characteristic type A intranuclear inclusions with peripheralization
MILLER JK, HESSER F, TOMPKINS VN. Herpes Simplex Encephalitis: Report of 20 Cases. Ann Intern Med. ;64:92–103. doi: 10.7326/0003-4819-64-1-92
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Published: Ann Intern Med. 1966;64(1):92-103.
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