ROBERT W. SCHRIER, M.D.; ROGER J. BULGER, M.D.; PAUL P. VANARSDEL JR., M.D., F.A.C.P.
Penicillin and its homologues are relatively nontoxic and even in high doses have no known renal toxicity in man (1, 2). By contrast, estimates of the frequency of allergic reactions have ranged from 1% to over 10% (3). In comparison to the more obvious and dramatic allergic reactions to penicillin, renal involvement has received little attention (4, 5). Acute anaphylaxis is obviously a major threat to life; but progressive renal damage may also be fatal, and its insidious development may not be recognized (6). However, only 22 cases of penicillin-related nephritis have appeared in the literature since Anderson (7) made
SCHRIER RW, BULGER RJ, VANARSDEL PP. Nephropathy Associated with Penicillin and Homologues. Ann Intern Med. 1966;64:116–127. doi: 10.7326/0003-4819-64-1-116
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Published: Ann Intern Med. 1966;64(1):116-127.
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