JOHN P. CAPELLI, M.D.; LAURENCE G. WESSON JR., M.D., F.A.C.P.; ALLAN V. ERSLEV, M.D., F.A.C.P.
The almost invariable association of anemia with the uremic state has long been recognized (1-3), and although it is generally agreed that the major cause of anemia in chronic renal insufficiency is depression of erythropoiesis (4, 5), the mechanism remains unknown. It has been suggested that the uremia per se inhibits erythropoiesis (6, 7), but the failure of the kidney to supply an erythropoietic hormone has been considered of greater importance. The concentration of this hormone in the serum of patients with uremia and anemia is considerably less than in other states of anemia, and although it does not appear
CAPELLI JP, WESSON LG, ERSLEV AV. Malignant Hypertension and Red Cell Fragmentation Syndrome: Report of a Case. Ann Intern Med. ;64:128–136. doi: 10.7326/0003-4819-64-1-128
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Published: Ann Intern Med. 1966;64(1):128-136.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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