ROBERT G. PETERSDORF, M.D.; MARVIN TURCK, M.D.
One of the truly remarkable developments in contemporary science is the discovery, synthesis, and clinical application of the penicillins. This story began in 1928 when Fleming (1) observed the lytic properties of the mold, Penicillium, on cultures of staphylococci. A full 12 years elapsed, however, before Chain, Florey, Jennings, and Williams (2) and Abraham and associates (3) in 1940 appreciated the potential usefulness of this preparation. Subsequently, penicillin research progressed at a rapid pace. The mold was produced on a large scale, and several members were added to the family by coupling of suitable side chains to fermentations of Penicillium.
PETERSDORF RG, TURCK M. The New Penicillins and Their Proper Use. Ann Intern Med. ;64:207–212. doi: 10.7326/0003-4819-64-1-207
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Published: Ann Intern Med. 1966;64(1):207-212.
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