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Dr. Constantinides' purpose in this monograph is to present work of the past decade which has produced in animals atherosclerotic lesions considered to be morphologically identical with those occurring in humans.
He first reviews the morphologic features of atherosclerosis in humans, then briefly describes the main current theories of pathogenesis, and argues for and against these theories. He proceeds to review animal experimental work, including his own, aimed at producing atherosclerotic lesions by "lipemia" (here taken to mean hypercholesterolemia) or by injury. His own work has involved the intermittent feeding of diets containing 1% cholesterol, a scheme by which lesions
Experimental Atherosclerosis.. Ann Intern Med. 1966;64:220. doi: 10.7326/0003-4819-64-1-220_1
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Published: Ann Intern Med. 1966;64(1):220.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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