JOHN I. LEVITT, M.D.
The differentiation between acute and chronic renal failure in a patient who presents with uremia is often extremely difficult. With the advent of artificial dialysis this distinction has become of more than academic interest, since most centers are prepared to temporarily dialyze the patient with acute renal failure in the hope of eventual recovery, whereas they are not prepared to do chronic dialysis on those patients with end-stage renal disease.
It was postulated that the concentration of creatinine in fingernail and toenail clippings might be of value in separating acute from chronic uremia. If nail creatinine concentration were a reflection
JOHN I. LEVITT. Creatinine Concentration of Human Fingernail and Toenail Clippings: Application in Determining the Duration of Renal Failure. Ann Intern Med. 1966;64:312–327. doi: 10.7326/0003-4819-64-2-312
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Published: Ann Intern Med. 1966;64(2):312-327.
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